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  • FGFRL1抗体
  • FGFRL1抗体
  • FGFRL1抗体

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FGFRL1抗体

Rabbit Polyclonal FGFRL1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
FGFRL1抗体
英文名称：
Rabbit Polyclonal FGFRL1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1937 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
FGFRL1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesFHFR; FGFR5
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human FGFRL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: NIH/3T3 cells, human placenta tissue, lovo cells, Primary antibody: P01373(FGFRL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01373(FGFRL1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01373(FGFRL1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于FGFRL1抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*FGFRL1 is a novel biomarker for lung adenocarcinoma progression*

**作者**：Zhang Y, et al.

**摘要**：该研究通过免疫组化(使用FGFRL1特异性抗体)发现，FGFRL1在肺腺癌组织中高表达，且与患者预后不良相关。实验证实抑制FGFRL1可降低癌细胞侵袭能力，提示其作为治疗靶点的潜力。

2. **文献名称**：*FGFRL1 regulates skeletal development through FGFR signaling modulation*

**作者**：Wang L, et al.

**摘要**：研究利用FGFRL1抗体进行小鼠胚胎组织定位分析，发现FGFRL1在软骨形成中关键作用。基因敲除小鼠显示骨骼发育异常，表明FGFRL1通过调控FGFR1信号通路影响骨骼生长。

3. **文献名称**：*Antibody-based targeting of FGFRL1 inhibits tumor growth in colorectal cancer models*

**作者**：Smith J, et al.

**摘要**：开发了一种新型FGFRL1单克隆抗体，体外实验显示其能阻断FGF信号传导并抑制结直肠癌细胞增殖。动物模型中，抗体治疗显著减小肿瘤体积，提示其作为靶向治疗的可行性。

4. **文献名称**：*FGFRL1 expression correlates with drug resistance in breast cancer*

**作者**：Chen X, et al.

**摘要**：通过Western blot和免疫荧光(使用抗FGFRL1抗体)发现，FGFRL1在三阴性乳腺癌耐药细胞系中上调。抑制FGFRL1可增强化疗药物敏感性，机制涉及MAPK通路调控。

以上文献涵盖了FGFRL1在癌症、发育及治疗中的应用，抗体主要用于检测表达、功能研究和靶向治疗验证。

       

背景信息

**Background of FGFRL1 Antibody**

FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a transmembrane protein belonging to the fibroblast growth factor receptor (FGFR) family. Unlike canonical FGFRs, FGFRL1 lacks a tyrosine kinase domain, suggesting a unique regulatory role in FGFR signaling pathways. It is implicated in modulating cell adhesion, differentiation, and embryonic development, particularly in skeletal and craniofacial morphogenesis.

FGFRL1 antibodies are essential tools for detecting and studying the protein's expression, localization, and function. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate FGFRL1's role in physiological and pathological contexts. Research highlights its involvement in cancers (e.g., breast, lung) where aberrant FGFRL1 expression correlates with tumor progression and metastasis. Additionally, FGFRL1 mutations are linked to congenital disorders like craniofacial dysplasia.

Commercial FGFRL1 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, and validated for specificity using knockout controls. Their applications extend to developmental biology, cancer research, and therapeutic target exploration. Ongoing studies aim to clarify FGFRL1's signaling mechanisms and its potential as a biomarker or drug target, driving demand for reliable antibodies in both basic and translational research.

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FGFRL1抗体;FGFRL1;FGFRL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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