FASTKD3抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01363(FASTKD3 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The FASTKD3 (FAS-activated serine/threonine kinase domains-containing protein 3) antibody is a tool used to study the FASTKD3 protein, a member of the FASTK family involved in mitochondrial RNA (mtRNA) metabolism and energy homeostasis. FASTKD3 localizes to mitochondria and plays a role in regulating mtRNA stability, processing, and translation, which are critical for oxidative phosphorylation and cellular energy production. Studies suggest its involvement in stress responses, apoptosis, and mitochondrial dynamics, linking it to neurodegenerative diseases, cancer, and metabolic disorders.

FASTKD3 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptide sequences or recombinant protein fragments. These antibodies enable the detection and analysis of FASTKD3 expression, localization, and interactions via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Specificity is validated through knockdown/knockout controls or competitive assays. Recent research highlights FASTKD3's potential as a biomarker or therapeutic target, particularly in conditions with mitochondrial dysfunction. Commercial antibodies often cite applications in both basic research and clinical studies, emphasizing their role in elucidating FASTKD3's regulatory mechanisms in health and disease.