FAIM2抗体

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12733(GAST Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of FAIM2 Antibody**

The Fas Apoptosis Inhibitory Molecule 2 (FAIM2), also known as Lifeguard (LFG), is a transmembrane protein that plays a critical role in regulating cell survival and apoptosis. It belongs to the FAIM protein family, which includes FAIM1 and FAIM2. both known for their anti-apoptotic functions. FAIM2 is predominantly expressed in the brain, particularly in neurons, where it inhibits Fas receptor-mediated apoptosis by interacting with Fas (CD95) and disrupting death-inducing signaling complex (DISC) formation. This mechanism helps maintain neuronal integrity and protects against neurodegenerative conditions.

FAIM2 antibodies are essential tools for studying its expression, localization, and functional roles in cellular and animal models. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate FAIM2's involvement in diseases such as Alzheimer's, Parkinson's, and cancer, where dysregulated apoptosis contributes to pathogenesis. Additionally, FAIM2 has been linked to metabolic regulation and immune responses, expanding its relevance beyond neuroscience.

The development of specific FAIM2 antibodies has advanced understanding of its structure-function relationships, including its N-terminal domain responsible for Fas binding and its C-terminal region involved in membrane anchoring. These antibodies also aid in exploring potential therapeutic strategies targeting FAIM2 to modulate apoptosis in disease contexts.