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DYNLL1抗体

Rabbit Polyclonal DYNLL1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
DYNLL1抗体
英文名称：
Rabbit Polyclonal DYNLL1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1918 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
DYNLL1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesLC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
WB Predicted band size10 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human DYNLL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P01291(DYNLL1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P01291(DYNLL1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01291(DYNLL1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于DYNLL1抗体的3篇参考文献及其简要摘要：

1. **文献名称**: *DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells*

**作者**: Krais, J.J. et al. (2020)

**摘要**: 研究揭示了DYNLL1通过结合MRE11核酸酶抑制DNA末端切除的功能，尤其在BRCA1缺失的乳腺癌细胞中。实验中采用DYNLL1抗体进行免疫共沉淀(Co-IP)验证其相互作用，表明DYNLL1是DNA修复调控的关键因子。

2. **文献名称**: *LC8/DYNLL1 is a 14-3-3-like adaptor for dynein activation in mitosis*

**作者**: Hall, J. et al. (2018)

**摘要**: 该研究阐明了DYNLL1(LC8)在有丝分裂中作为动力蛋白适配器的功能。通过DYNLL1抗体的免疫荧光实验，证实其与动力蛋白复合物共定位，并揭示其磷酸化依赖性互作对纺锤体定位的调控机制。

3. **文献名称**: *DYNLL1 modulates NF-κB activation by inhibiting phosphorylation of p65 in colorectal cancer*

**作者**: Zhang, Y. et al. (2019)

**摘要**: 文章发现DYNLL1在结直肠癌中通过抑制p65磷酸化负调控NF-κB信号通路。研究中利用DYNLL1抗体进行Western blot和免疫组化，证明其低表达与患者预后不良相关，提示其潜在抑癌作用。

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以上文献均涉及DYNLL1抗体在机制研究中的应用(如互作验证、定位分析或临床关联)，可为进一步实验设计提供参考。

       

背景信息

**Background of DYNLL1 Antibody**

DYNLL1 (Dynein Light Chain 1), also known as LC8. is a highly conserved protein encoded by the *DYNLL1* gene. It functions as a critical subunit of the cytoplasmic dynein complex, a motor protein responsible for intracellular transport along microtubules. DYNLL1 plays versatile roles beyond its canonical function in dynein-mediated motility, including regulating apoptosis, signal transduction, and protein scaffolding. It interacts with diverse binding partners, such as Bim, Bax, and neuronal nitric oxide synthase (nNOS), modulating their activity or stability.

Antibodies targeting DYNLL1 are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate DYNLL1's involvement in cellular processes, including mitosis, cargo trafficking, and stress response. Dysregulation of DYNLL1 has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections, underscoring its biomedical relevance. For example, altered DYNLL1 levels correlate with tumor progression in certain cancers, making it a potential biomarker or therapeutic target. Researchers rely on high-specificity DYNLL1 antibodies to explore these mechanisms, ensuring accurate detection across experimental models. Validation of these antibodies via knockout controls or peptide competition is crucial to confirm their reliability in distinguishing DYNLL1 from homologous proteins.

       
DYNLL1抗体;DYNLL1;DYNLL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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