DCTN6抗体

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P01278(DCTN6 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P01278(DCTN6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01278(DCTN6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The DCTN6 antibody targets the dynactin subunit 6 (DCTN6), a component of the dynactin complex, which plays a critical role in regulating dynein-mediated intracellular trafficking. Dynactin, a multi-subunit protein complex, interacts with cytoplasmic dynein-1 to facilitate retrograde transport of cargoes along microtubules. DCTN6. also known as p27. stabilizes the dynactin structure by linking the Arp1 filament to other subunits, ensuring proper dynein motor activity. Dysregulation of dynactin function is implicated in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Perry syndrome, as well as cancer metastasis.

DCTN6-specific antibodies are essential tools for studying dynactin assembly, intracellular transport mechanisms, and disease pathology. They enable detection of DCTN6 expression levels, localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Research using these antibodies has highlighted DCTN6's role in maintaining neuronal health and its potential as a biomarker or therapeutic target. However, variability in antibody specificity across studies underscores the need for rigorous validation to ensure accurate experimental outcomes. Overall, DCTN6 antibodies contribute to advancing understanding of cellular dynamics and disease mechanisms linked to microtubule-based transport.