CYFIP2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: P01247(CYFIP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01247(CYFIP2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P01247(CYFIP2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CYFIP2 (Cytoplasmic FMR1-Interacting Protein 2) antibody is a key tool for studying the role of CYFIP2. a protein involved in neuronal development, synaptic plasticity, and cellular signaling. CYFIP2 is part of the WAVE regulatory complex (WRC), which regulates actin cytoskeleton dynamics critical for cell motility, morphology, and synaptic function. It also interacts with FMRP (Fragile X Mental Retardation Protein), linking it to mRNA translation regulation and neurodevelopmental disorders like autism and Fragile X syndrome.

This antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect CYFIP2 expression and localization in tissues or cultured cells. Researchers employ it to investigate CYFIP2's involvement in neurological diseases, including Alzheimer’s disease, intellectual disabilities, and epilepsy, as altered CYFIP2 levels correlate with synaptic dysfunction. Specificity is validated through knockout (KO) controls or siRNA knockdown to ensure minimal cross-reactivity with its homolog CYFIP1.

Commercially available CYFIP2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Proper validation ensures reliability in both quantitative and qualitative analyses, aiding studies on CYFIP2’s regulatory mechanisms in health and disease. Its application continues to advance understanding of neuropathologies and potential therapeutic targets.