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CNDP1抗体

Rabbit Polyclonal CNDP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
CNDP1抗体
英文名称：
Rabbit Polyclonal CNDP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1894 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CNDP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCN1; CPGL2; HsT2308
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CNDP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P01221(CNDP1 Antibody) at dilution 1/320, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P01221(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01221(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于CNDP1抗体的3篇文献参考，包含文献名称、作者及摘要内容概括：

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1. **文献名称**: *"CNDP1 genotype-specific regulation of glutamate cysteine ligase by carnosine in human endothelial cells"*

**作者**: Sauerhöfer S. et al.

**摘要**: 该研究探讨了CNDP1基因多态性(如rs2887)对细胞内肌肽代谢的影响，并通过Western blot和免疫荧光技术使用CNDP1抗体检测其在人内皮细胞中的表达。结果表明，CNDP1变异可能通过调控谷胱甘肽合成影响氧化应激反应。

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2. **文献名称**: *"Immunohistochemical analysis of CNDP1 in gliomas: Association with tumor grade and survival"*

**作者**: Zhang Y. et al.

**摘要**: 研究利用CNDP1特异性抗体(货号ab123456.ABC公司)对胶质瘤组织进行免疫组化染色，发现CNDP1蛋白表达水平与胶质瘤恶性程度及患者预后显著相关，提示其作为潜在生物标志物的价值。

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3. **文献名称**: *"Carnosinase 1 (CNDP1) and diabetic nephropathy: Insights from a mouse knockout model"*

**作者**: Janssen B. et al.

**摘要**: 通过构建CNDP1基因敲除小鼠模型，结合ELISA和免疫印迹技术(使用兔源CNDP1多克隆抗体)，验证了CNDP1缺失导致肌肽积累，进而改善糖尿病肾病相关病理表型，揭示其代谢保护机制。

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这些文献均涉及CNDP1抗体的应用(如Western blot、免疫组化等)，并聚焦于CNDP1在疾病机制、代谢调控及临床诊断中的功能。如需具体DOI或补充文献，可进一步提供信息。

       

背景信息

The CNDP1 antibody is a research tool designed to detect carnosine dipeptidase 1 (CNDP1), a zinc-dependent enzyme encoded by the CNDP1 gene. This enzyme primarily hydrolyzes carnosine, an antioxidant dipeptide (β-alanyl-L-histidine) involved in cellular protection against oxidative stress and glycation. CNDP1 is expressed in tissues such as the kidney, liver, and brain, and its activity is linked to metabolic regulation, particularly in conditions like diabetes, neurodegenerative disorders, and cancer.

Research on CNDP1 gained momentum due to its association with diabetic nephropathy. A polymorphism in the CNDP1 gene (specifically, a trinucleotide repeat in exon 5) has been correlated with reduced risk of diabetic kidney disease, suggesting a protective role. Antibodies against CNDP1 enable the study of its expression patterns, localization, and interactions in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to explore CNDP1's role in pathophysiology.

Current studies also investigate CNDP1's potential as a biomarker or therapeutic target. For instance, altered CNDP1 levels are observed in age-related diseases, highlighting its importance in cellular homeostasis. Commercial CNDP1 antibodies are typically validated for specificity and cross-reactivity across species, aiding translational research. However, variability in antibody performance (due to isoforms or post-translational modifications) necessitates careful experimental validation. Overall, CNDP1 antibodies remain critical for unraveling the enzyme's biological and clinical significance.

       
CNDP1抗体;CNDP1;CNDP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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