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PLEKHO1抗体

Rabbit Polyclonal PLEKHO1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
PLEKHO1抗体
英文名称：
Rabbit Polyclonal PLEKHO1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1893 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PLEKHO1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesOC120; CKIP-1; RP11-458I7.3
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PLEKHO1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, mouse muscle tissue, Mouse kidney tissue, Primary antibody: P01216(PLEKHO1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01216(PLEKHO1 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01216(PLEKHO1 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是3篇与PLEKHO1(CKIP-1)抗体相关的代表性文献，包含文献名称、作者及摘要内容概括：

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1. **文献名称**：*CKIP-1 regulates osteoblast differentiation via controlling MOB1 acetylation*

**作者**：Zhang Y et al.

**摘要**：研究利用PLEKHO1抗体进行Western blot和免疫荧光实验，发现CKIP-1通过调控Hippo信号通路关键蛋白MOB1的乙酰化水平，影响成骨细胞分化，为骨代谢疾病治疗提供新靶点。

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2. **文献名称**：*PLEKHO1 modulates tumor microenvironment and limits efficacy of immune checkpoint blockade*

**作者**：Chen L et al.

**摘要**：通过免疫组化(使用PLEKHO1抗体)和单细胞测序，揭示PLEKHO1在肿瘤相关巨噬细胞中高表达，抑制T细胞活性，导致免疫检查点抑制剂治疗抵抗，提示其作为癌症治疗联合靶点的潜力。

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3. **文献名称**：*Structural basis of CKIP-1 recognition by the SCFβ-TrCP ubiquitin ligase*

**作者**：Wang X et al.

**摘要**：结合X射线晶体学及PLEKHO1抗体的免疫共沉淀实验，解析了CKIP-1与SCFβ-TrCP复合物的相互作用结构，阐明其通过泛素化降解调控Wnt/β-catenin信号通路的分子机制。

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**备注**：若需获取全文，建议通过PubMed或ResearchGate检索标题及作者，部分文献可能为开放获取(Open Access)。

       

背景信息

The PLEKHO1 (Pleckstrin Homology Domain-Containing Family O Member 1) antibody is a tool used to study the PLEKHO1 protein, also known as CKIP-1 (Casein Kinase 2-Interacting Protein 1). This protein plays a regulatory role in multiple cellular processes, including cell proliferation, apoptosis, cytoskeletal organization, and bone formation. It interacts with signaling pathways such as the PI3K/AKT and Wnt/β-catenin cascades, often acting as a scaffold or adaptor protein. PLEKHO1 is implicated in diseases like cancer, osteoporosis, and cardiovascular disorders, making it a target for therapeutic research.

The antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PLEKHO1 expression, localization, and interactions in cells or tissues. Studies using this antibody have revealed PLEKHO1’s role in tumor suppression (e.g., inhibiting lung cancer metastasis) or promotion (context-dependent), bone metabolism (modulating osteoblast activity), and cardiac remodeling. Its development often involves immunizing hosts with peptide antigens specific to conserved regions of the human or murine PLEKHO1 protein, followed by purification and validation for specificity. Researchers rely on this antibody to explore PLEKHO1’s molecular mechanisms, potential as a biomarker, or as a target for drug development in precision medicine.

       
PLEKHO1抗体;PLEKHO1;PLEKHO1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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