CENPJ抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01202(CENPJ Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

CENPJ (Centromere Protein J), also known as CPAP (Centrosomal-P4.1-Associated Protein), is a key protein involved in centrosome and centriole biogenesis, playing a critical role in cell division, microtubule organization, and chromosomal stability. It localizes to the centrosome, where it regulates the assembly and elongation of centrioles, ensuring proper spindle formation during mitosis and meiosis. Dysregulation of CENPJ is linked to microcephaly, a neurodevelopmental disorder characterized by reduced brain size, as well as cancer progression due to genomic instability caused by centrosome aberrations.

CENPJ antibodies are essential tools for studying centrosome dynamics, cell cycle regulation, and diseases associated with centrosomal defects. In research, these antibodies are widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize CENPJ expression, localization, and interaction partners. They help elucidate mechanisms underlying centriole duplication errors, mitotic defects, and pathological conditions such as primary microcephaly or cancer. Commercially available CENPJ antibodies are typically validated for specificity against human, mouse, or other model organisms, enabling cross-species studies. Their applications extend to screening therapeutic targets for diseases linked to centrosomal dysfunction.