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SPN抗体

Rabbit Polyclonal SPN Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
SPN抗体
英文名称：
Rabbit Polyclonal SPN Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1883 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SPN

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPOMC; LPH; MSH; NPP; POC; CLIP
Entrez GeneID5443
clone3A4H4
WB Predicted band size29.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ACTH expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using ACTH mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ACTH mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of MCF-7 cells using ACTH mouse mAb (green) and negative control (red).    


           

参考文献

以下是3篇关于SPN(Sialophorin/CD43)抗体的代表性文献摘要概括，按研究领域分类整理：

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1. **文献名称**：*"Structural characterization of sialophorin (CD43) as a keratin sulfate proteoglycan in human T-lymphoblasts"*

**作者**：Fukuda M. et al.

**摘要**：通过单克隆抗体分析，揭示了SPN(CD43)在T淋巴细胞表面作为硫酸角质素蛋白聚糖的分子结构，证实其N端糖基化修饰与免疫细胞黏附功能相关。

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2. **文献名称**：*"CD43 modulates the differentiation and function of dendritic cells through TLR4 signaling"*

**作者**：Santos-Sierra S. & Corral R.

**摘要**：研究利用抗SPN抗体阻断实验，证明CD43通过TLR4信号通路调控树突状细胞的成熟及抗原呈递能力，影响先天性免疫应答。

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3. **文献名称**：*"SPN/CD43 loss correlates with poor prognosis in diffuse large B-cell lymphoma"*

**作者**：Li Y. et al.

**摘要**：通过免疫组化分析发现，SPN表达缺失与弥漫大B细胞淋巴瘤患者生存率下降显著相关，提示其作为潜在预后标志物的临床价值。

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**领域覆盖**：

- **结构生物学**(文献1解析分子构象)

- **免疫调控**(文献2揭示信号通路机制)

- **肿瘤诊断**(文献3探索临床相关性)

如需特定方向文献补充，可进一步说明研究需求。

       

背景信息

**Background of SPN Antibody**

SPN (sialophorin), also known as CD43. is a heavily glycosylated transmembrane protein predominantly expressed on the surface of immune cells, including T cells, B cells, neutrophils, and natural killer (NK) cells. It belongs to the sialomucin family, characterized by extensive O-linked glycosylation and a high content of sialic acid, which confers a strong negative charge. This charge contributes to its role in repelling cell-cell interactions, modulating immune responses, and regulating cell adhesion and migration.

SPN plays a dual role in immune regulation. It acts as both a physical barrier against undesired cellular interactions and a signaling molecule involved in T-cell activation, apoptosis, and cytokine production. Its cytoplasmic domain interacts with cytoskeletal proteins and signaling molecules, influencing intracellular pathways. Dysregulation of SPN expression has been linked to immunodeficiency, autoimmune diseases, and hematologic malignancies, such as leukemia and lymphoma.

SPN antibodies are essential tools in research and diagnostics. They enable the detection of SPN/CD43 in flow cytometry, immunohistochemistry, and Western blotting, aiding in immune cell characterization and disease profiling. In clinical settings, SPN antibodies help diagnose lymphoproliferative disorders, as abnormal SPN expression often serves as a marker for malignant cell populations. Studies continue to explore SPN’s therapeutic potential, including targeting its immunosuppressive effects in cancer.

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SPN抗体;SPN;SPN Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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