CARD8抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

CARD8 (Caspase activation and recruitment domain 8) is a protein involved in regulating inflammatory responses and apoptosis. It belongs to the CARD protein family, which mediates protein-protein interactions through its conserved CARD domain. Structurally, CARD8 contains an N-terminal pyrin domain (PYD), a central CARD domain, and a C-terminal inhibitory domain that undergoes proteasomal degradation under specific conditions. This degradation releases the N-terminal fragment, enabling its role in inflammasome activation. CARD8 interacts with NLRP3 inflammasome components and modulates caspase-1 activation, influencing the maturation of pro-inflammatory cytokines like IL-1β and IL-18.

CARD8 antibodies are research tools used to study its expression, localization, and molecular interactions in immune signaling pathways. Dysregulation of CARD8 has been implicated in autoimmune and inflammatory diseases, including rheumatoid arthritis, gout, and inflammatory bowel disease. Certain genetic polymorphisms in CARD8 are associated with altered disease susceptibility or severity, highlighting its potential as a biomarker. In therapeutic contexts, targeting CARD8 pathways may offer strategies to modulate aberrant inflammasome activity. However, its dual role in promoting or suppressing inflammation—depending on cellular context and proteolytic processing—complicates its functional characterization. Current studies employ CARD8 antibodies in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to unravel its mechanisms in health and disease. Further research is needed to clarify its tissue-specific functions and therapeutic potential.