NCAPD2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, hela cells, Primary antibody: P01153(NCAPD2 Antibody) at dilution 1/425, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01153(NCAPD2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01153(NCAPD2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The NCAPD2 antibody targets the Non-SMC Condensin II Complex Subunit D2 (NCAPD2), a key component of the condensin II complex involved in chromosome condensation and segregation during mitosis. NCAPD2 plays a critical role in maintaining genomic stability by ensuring proper chromatin organization and sister chromatid resolution. Dysregulation of NCAPD2 has been linked to chromosomal instability, aneuploidy, and carcinogenesis, making it a focus in cancer biology and genetic disorder research.

Antibodies against NCAPD2 are widely used in molecular and cellular studies to investigate its expression, localization, and interaction partners. They enable techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore NCAPD2's role in cell cycle regulation, DNA repair, and transcriptional control. These antibodies are particularly valuable in cancer research, where altered NCAPD2 expression has been observed in tumors such as glioblastoma, hepatocellular carcinoma, and breast cancer.

Commercial NCAPD2 antibodies are typically raised in hosts like rabbits or mice, with validation including knockout cell line controls to confirm specificity. Researchers also utilize these reagents to study developmental defects linked to condensin II dysfunction. Proper validation remains essential due to potential cross-reactivity with structurally similar condensin subunits.