CAMK1D抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01150(CAMK1D Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01150(CAMK1D Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The CAMK1D antibody is a crucial tool for studying the calcium/calmodulin-dependent protein kinase 1 delta (CAMK1D), a serine/threonine kinase belonging to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) family. CAMK1D is encoded by the CAMK1D gene and plays a role in calcium-mediated signaling pathways, regulating cellular processes such as gene transcription, cell cycle progression, and metabolism. It is activated by calcium/calmodulin binding and further phosphorylated by upstream kinases like CAMKK, enabling its full enzymatic activity. CAMK1D is expressed in various tissues, including the brain, pancreas, and immune cells, and has been implicated in diseases such as cancer, diabetes, and neurological disorders.

The CAMK1D antibody is specifically designed to detect endogenous CAMK1D protein levels in applications like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to investigate CAMK1D's expression patterns, post-translational modifications (e.g., phosphorylation at Thr180), and interactions within signaling cascades. Validated antibodies typically target epitopes within the kinase domain or regulatory regions, ensuring specificity by distinguishing CAMK1D from closely related isoforms (e.g., CAMK1. CAMK1G). Its development supports mechanistic studies of CAMK1D's role in cellular responses to calcium fluctuations, metabolic regulation, and pathological conditions, making it essential for both basic research and therapeutic target validation.