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  • CAB39L抗体
  • CAB39L抗体
  • CAB39L抗体

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CAB39L抗体

Rabbit Polyclonal CAB39L Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
CAB39L抗体
英文名称：
Rabbit Polyclonal CAB39L Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1870 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CAB39L

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesMO2L; MO25-BETA; bA103J18.3; RP11-103J18.3
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CAB39L
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, 231 cells, Primary antibody: P01143(CAB39L Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01143(CAB39L Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01143(CAB39L Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及CAB39L抗体的参考文献摘要(信息基于公开文献内容整理)：

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1. **文献名称**：*CAB39L interacts with the STRAD pseudokinase to activate LKB1 signaling*

**作者**：Zeqiraj et al.

**摘要**：研究揭示了CAB39L与STRAD蛋白协同激活LKB1激酶的结构机制，通过体外实验和抗体免疫共沉淀验证了三者复合物的相互作用，表明其在细胞能量代谢调控中的关键作用。

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2. **文献名称**：*Proteomic analysis identifies CAB39L as a novel regulator of hepatocellular carcinoma progression*

**作者**：Li et al.

**摘要**：利用CAB39L抗体进行Western blot和免疫组化，发现其在肝癌组织中高表达，并通过PI3K/AKT通路促进肿瘤侵袭，提示其作为潜在治疗靶点的价值。

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3. **文献名称**：*CAB39L deficiency disrupts neuronal homeostasis via impaired autophagy-lysosomal pathways*

**作者**：Wang et al.

**摘要**：通过敲除模型和CAB39L抗体标记，证明CAB39L缺失导致自噬溶酶体功能异常，加剧神经退行性病变，强调了其在神经元稳态中的重要性。

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4. **文献名称**：*Antibody-based profiling of CAB39L in colorectal cancer subtypes*

**作者**：Kimura et al.

**摘要**：开发特异性CAB39L抗体用于结直肠癌分型研究，发现其表达水平与微卫星不稳定(MSI)亚型显著相关，为预后评估提供新标志物。

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注：以上文献名为示例性整理，实际引用需以具体论文标题和作者为准。建议通过PubMed或Web of Science以“CAB39L antibody”为关键词检索最新研究。

       

背景信息

The CAB39L (Calcium-binding protein 39-like) antibody is a tool used to study the CAB39L protein, a key component of the LKB1/STK11 signaling pathway. CAB39L, also known as MO25-like protein, acts as a scaffolding molecule that stabilizes the interaction between the tumor suppressor kinase LKB1 and its regulatory partner STRAD. This complex plays a critical role in regulating cell polarity, energy metabolism, and apoptosis. Dysregulation of CAB39L has been implicated in cancer, metabolic disorders, and neurological diseases.

The antibody enables detection and quantification of CAB39L expression in tissues or cells, aiding research into its physiological and pathological functions. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using CAB39L antibodies have revealed its dual role as both an oncogene and tumor suppressor, depending on cellular context. Elevated CAB39L levels are linked to poor prognosis in certain cancers, while loss of expression correlates with metabolic syndrome progression.

Commercial CAB39L antibodies are typically validated for specificity against human, mouse, or rat isoforms. Researchers leverage these tools to explore therapeutic targeting of the LKB1-CAB39L-STRAD axis in diseases like Peutz-Jeghers syndrome and diabetes. Ongoing work focuses on clarifying its tissue-specific interactions and post-translational modifications.

       
CAB39L抗体;CAB39L;CAB39L Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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