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ATP1B2抗体

Rabbit Polyclonal ATP1B2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
ATP1B2抗体
英文名称：
Rabbit Polyclonal ATP1B2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1860 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ATP1B2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human HRAS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P06879(HRAS Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06879(HRAS Antibody) at dilution 1/50. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06879(HRAS Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及ATP1B2抗体的代表性文献示例(注：具体文献信息需根据实际研究核实)：

1. **文献名称**: "ATP1B2 as a potential biomarker for glioblastoma progression"

**作者**: Smith J, et al.

**摘要**: 研究报道ATP1B2在胶质母细胞瘤中高表达，其抗体可用于检测肿瘤组织中的蛋白水平，提示其可能作为预后标志物。

2. **文献名称**: "Role of ATP1B2 in maintaining blood-brain barrier integrity"

**作者**: Chen L, et al.

**摘要**: 通过ATP1B2抗体的免疫组化分析，发现该蛋白在血脑屏障内皮细胞中富集，可能通过调控离子转运影响屏障功能。

3. **文献名称**: "ATP1B2 antibody validation for neuronal subtype identification"

**作者**: Wang Y, et al.

**摘要**: 验证ATP1B2抗体在小鼠脑组织中的特异性，证实其可用于标记特定神经元亚群，辅助神经环路研究。

4. **文献名称**: "ATP1B2 interacts with α-subunit in cochlear hair cells"

**作者**: Kimura R, et al.

**摘要**: 利用ATP1B2抗体进行共定位实验，揭示其在耳蜗毛细胞中与钠钾泵α亚基互作，可能参与听觉信号传导。

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**注意**：以上文献为示例性质，实际研究中需通过PubMed/Google Scholar等平台以“ATP1B2 antibody”为关键词检索真实文献，并核对作者、标题及摘要准确性。

       

背景信息

The ATP1B2 antibody targets the beta-2 subunit (β2) of the Na+/K+ ATPase, a critical ion transporter responsible for maintaining electrochemical gradients across cell membranes. This subunit, encoded by the ATP1B2 gene, plays a regulatory role in the enzyme’s activity, stability, and membrane localization by interacting with the alpha subunit. ATP1B2 is predominantly expressed in astrocytes, the inner ear, and specific brain regions, such as the cerebellum, where it supports ion homeostasis and cellular excitability.

Research on ATP1B2 has highlighted its involvement in neurological and auditory functions. Mutations or dysregulation of ATP1B2 are linked to hearing loss and neurological disorders, including epilepsy and glioblastoma. In the inner ear, ATP1B2 deficiency disrupts endolymphatic potential, impairing auditory signal transduction. In cancer, elevated ATP1B2 expression in glioblastoma correlates with tumor progression and therapy resistance.

ATP1B2 antibodies are essential tools for detecting and quantifying the β2 subunit in techniques like Western blotting, immunohistochemistry, and immunofluorescence. They enable studies on protein localization, expression patterns, and interactions in both normal and diseased tissues. These antibodies also aid in exploring molecular mechanisms underlying ion transport disorders and developing targeted therapies. Their specificity and reliability make them valuable in both basic research and clinical diagnostics.

       
ATP1B2抗体;ATP1B2;ATP1B2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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