ASB10抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cell lysate, Primary antibody: P01110(ASB10 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

The ASB10 antibody is a research tool targeting the Ankyrin Repeat and SOCS Box Protein 10 (ASB10), a member of the ASB family involved in cellular protein degradation pathways. ASB proteins typically function as substrate-recognition components of E3 ubiquitin ligase complexes, mediating ubiquitination and subsequent proteasomal degradation of specific target proteins. ASB10 contains characteristic ankyrin repeats for protein interactions and a SOCS box domain that binds elongin B/C to form E3 ligase complexes.

While the biological roles of ASB10 remain incompletely defined, studies suggest its involvement in ocular physiology, particularly aqueous humor dynamics and intraocular pressure regulation. Dysregulation of ASB10 expression has been linked to glaucoma pathogenesis. Emerging evidence also implicates ASB10 in cancer progression, with altered expression observed in certain malignancies.

ASB10 antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions. These reagents facilitate exploration of ASB10's physiological functions and its potential as a diagnostic marker or therapeutic target. Ongoing research aims to identify its endogenous substrates and clarify its regulatory mechanisms in both normal and pathological states.