AURKAIP1抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P01101(AURKAIP1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The AURKAIP1 antibody is a research tool designed to detect Aurora Kinase A Interacting Protein 1 (AURKAIP1), a conserved mitochondrial protein implicated in cell cycle regulation and mitochondrial function. AURKAIP1. also known as antisense RNA to AURKA, interacts with Aurora Kinase A (AURKA), a key serine/threonine kinase involved in mitotic progression, centrosome maturation, and spindle assembly. While AURKA is overexpressed in various cancers and linked to genomic instability, AURKAIP1 is thought to modulate its activity or stability, potentially acting as a regulatory factor. Studies suggest AURKAIP1 localizes to mitochondria and may play a role in maintaining mitochondrial integrity during stress, though its precise molecular mechanisms remain under investigation.

This antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study AURKAIP1 expression, subcellular localization, and interaction networks. Researchers employ it to explore AURKAIP1's involvement in diseases such as cancer, neurodevelopmental disorders, or conditions tied to mitochondrial dysfunction. Its specificity is typically validated using knockout controls or siRNA-mediated knockdown. Commercial AURKAIP1 antibodies are available from multiple suppliers, often raised in hosts like rabbits or mice, with validation data provided for specific applications. Proper experimental controls are essential due to potential cross-reactivity with homologous proteins or splice variants.