CAPRIN1抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cell lysate, Primary antibody: P01070(CAPRIN1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01070(CAPRIN1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01070(CAPRIN1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

CAPRIN1 (Cell cycle-associated protein 1) is a multifunctional RNA-binding protein involved in regulating mRNA translation, cell proliferation, and stress granule formation. It plays critical roles in cell cycle progression, particularly during the G1/S phase transition, and is implicated in cancer development, neurodevelopmental disorders, and immune responses. CAPRIN1 interacts with proteins like G3BP1 to modulate stress granule dynamics under cellular stress and influences pathways such as Wnt/β-catenin signaling.

CAPRIN1 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry (IHC) to investigate CAPRIN1's overexpression in cancers (e.g., breast cancer, hepatocellular carcinoma) and its association with tumor aggressiveness. Commercially available antibodies target specific epitopes, with validation often performed using knockout cell lines or recombinant protein controls. Recent studies highlight CAPRIN1's potential as a therapeutic target, particularly in cancers where it promotes metastasis and chemoresistance. However, antibody specificity remains a consideration due to protein isoforms and post-translational modifications. Ongoing research continues to explore CAPRIN1's roles in neurodegenerative diseases like Alzheimer's, expanding the utility of these antibodies in diverse biomedical contexts.