GSTA2抗体

The glutathione S-transferase alpha 2 (GSTA2) antibody is a tool used to detect and study the GSTA2 protein, a member of the glutathione S-transferase (GST) family. GSTs are phase II detoxification enzymes that catalyze the conjugation of glutathione to electrophilic substrates, facilitating the metabolism of xenobiotics, carcinogens, and reactive oxygen species. GSTA2. specifically, is highly expressed in the liver and plays a critical role in cellular protection against oxidative stress, chemical toxins, and drug metabolites. It is implicated in diseases such as cancer, liver disorders, and neurodegenerative conditions. Researchers use GSTA2 antibodies in techniques like Western blotting, immunohistochemistry, and ELISA to analyze protein expression levels, tissue localization, and its association with disease mechanisms or drug resistance. Commercially available GSTA2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human GSTA2 protein. Studies involving this antibody contribute to understanding detoxification pathways, biomarker discovery, and therapeutic targeting in conditions linked to GSTA2 dysregulation. Validation of antibody specificity through knockout controls or peptide blocking is essential for reliable experimental results.