UCK1抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01049(UCK1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01049(UCK1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The UCK1 (uridine-cytidine kinase 1) antibody is a tool used to study the UCK1 enzyme, a key player in the pyrimidine salvage pathway. UCK1 catalyzes the phosphorylation of uridine and cytidine to their monophosphate forms (UMP/CMP), a critical step in RNA synthesis and cellular proliferation. This 22-24 kDa protein, encoded by the *UCK1* gene in humans, is primarily expressed in the liver, kidney, and certain cancer cells.

Research on UCK1 has gained attention due to its role in activating prodrugs like 5-fluorouridine (5-FU) in chemotherapy, linking it to cancer treatment efficacy. Overexpression of UCK1 has been observed in hepatocellular carcinoma and colorectal cancer, suggesting its potential as a therapeutic target or biomarker.

UCK1 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect UCK1 expression levels, subcellular localization, and interactions in disease models. They help elucidate UCK1's regulatory mechanisms, including post-translational modifications and its interplay with signaling pathways like mTOR. Specificity validation via knockout controls is essential due to structural similarities with UCK2. a paralog with overlapping functions.

Overall, UCK1 antibodies serve as vital reagents in exploring nucleotide metabolism dysregulation, cancer biology, and drug development strategies.