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MARK1抗体

Rabbit Polyclonal MARK1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
MARK1抗体
英文名称：
Rabbit Polyclonal MARK1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1834 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MARK1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Entrez GeneID718
clone8B5H2
WB Predicted band size187.1kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human C3C (AA: 1521-1649) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C3C mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using C3C mouse mAb with DAB staining.    


           

参考文献

以下是关于MARK1抗体的3篇参考文献及其摘要概括：

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1. **文献名称**：*MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption*

**作者**：Drewes G., et al.

**摘要**：该研究首次鉴定了哺乳动物中的MARK激酶家族(包括MARK1)，发现其通过磷酸化微管相关蛋白(如tau)导致微管结构解体。研究使用特异性抗体证实MARK1在调控神经元微管稳定性中的作用，与阿尔茨海默病中tau病理相关。

2. **文献名称**：*The role of PAR-1/MARK kinase in microtubule dynamics and cytoskeletal organization*

**作者**：Trinczek B., et al.

**摘要**：通过免疫荧光和Western blot分析，研究发现MARK1(PAR-1)抗体标记显示其在细胞分裂和极性形成中的定位。实验表明MARK1通过磷酸化调控微管结合蛋白，影响细胞骨架重组与神经元形态发生。

3. **文献名称**：*MARK/Par-1 kinase is activated through a PKC-dependent pathway and regulates microtubule dynamics*

**作者**：Matenia D., et al.

**摘要**：该文献利用MARK1特异性抗体揭示其在神经元中的表达模式，并发现其活性受PKC信号调控。研究证明MARK1磷酸化tau蛋白，导致微管网络动态失衡，提示其在神经退行性疾病中的潜在机制。

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以上文献均涉及MARK1抗体的应用，涵盖其功能验证、亚细胞定位及与疾病相关的分子机制。如需具体实验细节，可进一步查阅全文。

       

背景信息

The MARK1 (Microtubule Affinity-Regulating Kinase 1) antibody is a crucial tool for studying the function and regulation of the MARK1 protein, a serine/threonine kinase belonging to the PAR1 (Partitioning Defective 1) family. MARK1 plays a pivotal role in establishing cell polarity, regulating microtubule dynamics, and maintaining neuronal integrity by phosphorylating microtubule-associated proteins (e.g., tau, MAP2/4). This phosphorylation destabilizes microtubule binding, influencing cellular architecture and trafficking. Dysregulation of MARK1 is implicated in neurodegenerative diseases, particularly Alzheimer’s disease, where hyperphosphorylated tau forms neurofibrillary tangles.

The MARK1 antibody enables detection and quantification of MARK1 expression in various experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. It helps elucidate MARK1's interaction networks, activity under stress or disease conditions, and its role in signaling pathways like Wnt or AMPK. Researchers also use it to study MARK1's involvement in developmental processes, cancer (cell cycle disruption), and synaptic plasticity.

Commercial MARK1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout controls to ensure specificity. Its applications span basic research, drug discovery, and diagnostic development, making it indispensable for exploring MARK1's dual roles in physiological homeostasis and pathological mechanisms. Ongoing studies focus on its therapeutic potential in targeting tauopathies and cancer metastasis.

       
MARK1抗体;MARK1;MARK1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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