HIPK4抗体

HIPA antibody targets Homeodomain-Interacting Protein Kinase 4 (HIPK4), a member of the HIPK family of serine/threonine kinases involved in diverse cellular processes, including DNA damage response, transcriptional regulation, and apoptosis. HIPK4. less characterized compared to HIPK1-3. shares a conserved kinase domain but exhibits distinct structural features, such as a unique N-terminal region and lack of a homodimerization domain. It is predominantly expressed in the testis, suggesting a specialized role in spermatogenesis, particularly in chromatin condensation and meiotic progression. Studies link HIPK4 dysfunction to male infertility due to impaired sperm maturation. HIPK4 antibodies are essential tools for detecting HIPK4 expression, localization, and interaction partners in research. They enable investigations into its kinase activity, substrate specificity, and regulatory mechanisms using techniques like Western blot, immunohistochemistry, and immunofluorescence. Recent work highlights HIPK4's potential involvement in cancer and neurodegenerative diseases, though its precise molecular pathways remain unclear. Reliable HIPK4 antibodies aid in elucidating its biological significance and therapeutic potential, addressing gaps in understanding its context-dependent roles and signaling networks.