PAPSS1抗体

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     Western blot analysis using AAT mouse mAb against human plasma (1) and NIH/3T3 cell lysate (2).    

  
  

**Background of PAPSS1 Antibody**

The PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) antibody is a tool used to detect and study the PAPSS1 enzyme, a key player in cellular sulfation pathways. PAPSS1 catalyzes the synthesis of 3'-phosphoadenosine-5'-phosphosulfate (PAPS), the universal sulfate donor for sulfotransferase-mediated reactions. These reactions are critical for sulfating diverse substrates, including proteoglycans, hormones, neurotransmitters, and xenobiotics, influencing their stability, activity, and clearance.

PAPSS1 localizes primarily to the cytosol and nucleus, with tissue-specific expression in the liver, cartilage, and adrenal glands. Dysregulation of PAPSS1 is linked to skeletal disorders (e.g., brachyolmia), hormonal imbalances, and cancer progression. For instance, reduced PAPSS1 expression may impair sulfation of extracellular matrix components, contributing to tumor metastasis or cartilage defects.

The PAPSS1 antibody enables researchers to investigate protein expression, subcellular localization, and molecular interactions in various models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies leveraging this antibody have clarified PAPSS1's role in metabolic regulation, developmental biology, and disease mechanisms. Its specificity and reliability make it essential for exploring PAPSS1's contributions to sulfation-dependent processes and potential therapeutic targets.