EPS15L1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, PC3 cells, 231 cells, 293T cells, Primary antibody: P01002(EPS15L1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01002(EPS15L1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01002(EPS15L1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1) antibody is a tool used to study the EPS15L1 protein, a homolog of the EPS15 protein involved in clathrin-mediated endocytosis and receptor tyrosine kinase signaling. EPS15L1 shares structural features with EPS15. including EH domains and coiled-coil regions, but exhibits distinct expression patterns and regulatory roles. Research suggests EPS15L1 may functionally overlap with EPS15 in endocytic trafficking, yet also participate in unique cellular processes such as cytoskeletal organization and vesicle formation.

Studies using EPS15L1 antibodies (often raised in rabbits or mice) have helped characterize its localization at clathrin-coated pits, interaction with endocytic machinery (e.g., AP-2 complex), and involvement in diseases like cancer. For example, EPS15L1 dysregulation has been linked to tumor progression and metastasis, possibly through modulating EGFR trafficking. Antibody-based assays (Western blot, immunofluorescence) have revealed tissue-specific expression profiles and phosphorylation dynamics under signaling stimuli.

While EPS15/EPS15L1 double-knockout models show embryonic lethality in mice, single deletions suggest partial functional redundancy. Ongoing research employs EPS15L1 antibodies to clarify its precise molecular mechanisms and therapeutic potential. Commercial antibodies are typically validated for specificity using knockout cell lines, aiding investigations into its role in neurodegeneration and receptor recycling pathways.