TLR5抗体

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     IHC-P analysis of pancreas tissue by SPINK1 antibody (P15936) IHC-P was performed using sections of the formalin-fixed paraffin-embedded pancreas tissue;Result: Exocrine glandular cells are positively stained at the cytoplasm.    

  
  

Toll-like receptor 5 (TLR5) is a transmembrane pattern recognition receptor that plays a critical role in innate immunity by detecting bacterial flagellin, a structural protein of bacterial flagella. Upon ligand binding, TLR5 activates downstream signaling pathways (e.g., MyD88/NF-κB) to trigger pro-inflammatory cytokine production and initiate antimicrobial responses. TLR5 is expressed on immune cells (e.g., dendritic cells, macrophages) and epithelial cells, serving as a frontline defense against pathogenic bacteria like Salmonella and Pseudomonas aeruginosa.

TLR5 antibodies are essential tools for studying its expression, localization, and functional mechanisms. Monoclonal and polyclonal antibodies targeting specific domains (e.g., extracellular leucine-rich repeats or intracellular TIR domain) enable applications such as Western blotting, immunohistochemistry, and flow cytometry. Neutralizing TLR5 antibodies are used to block flagellin-TLR5 interactions in mechanistic studies or therapeutic explorations. Dysregulation of TLR5 signaling has been implicated in infections, inflammatory bowel disease, and cancer, making TLR5 antibodies valuable for both basic research and drug development. Recent studies also explore TLR5 agonists/antagonists as potential immunomodulators, highlighting the antibody's dual utility in diagnostics and therapy.