SPIRE2抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00970(SPIRE2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00970(SPIRE2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SPIRE2 antibody is a research tool designed to detect and study the SPIRE2 protein, a member of the SPIRE (Spi/A actin organization protein) family. SPIRE2. encoded by the *SPIRE2* gene in humans, is an actin-nucleating factor that regulates cytoskeletal dynamics by interacting with formin proteins and the ARP2/3 complex. It plays roles in intracellular trafficking, organelle positioning, and cell motility by orchestrating actin filament assembly. SPIRE2 is particularly noted for its involvement in vesicle transport processes, such as endosomal trafficking and Golgi-lysosome dynamics, and has been linked to developmental pathways, including oocyte maturation and embryogenesis.

Antibodies targeting SPIRE2 are typically developed in immunized hosts (e.g., rabbits or mice) using recombinant protein fragments or synthetic peptides as antigens. These antibodies enable detection of SPIRE2 in techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the study of its expression, subcellular localization, and interactions. Research utilizing SPIRE2 antibodies has explored its functional roles in cancer progression, neuronal development, and immune cell regulation. Dysregulation of SPIRE2 has been implicated in metastatic cancers, where aberrant cytoskeletal remodeling promotes invasion. Additionally, studies suggest SPIRE2 may influence ciliogenesis and autophagy, highlighting its broad regulatory scope. As a reagent, SPIRE2 antibodies are critical for dissecting molecular mechanisms in cell biology and disease models.