ARHGAP15抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, 293T cells, Primary antibody: P00952(ARHGAP15 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00952(ARHGAP15 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00952(ARHGAP15 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ARHGAP15 antibody is a research tool designed to detect and study the ARHGAP15 protein, a member of the Rho GTPase-activating protein (RhoGAP) family. ARHGAP15 functions as a negative regulator of Rho GTPases, particularly Rac1 and Cdc42. by enhancing their intrinsic GTPase activity to promote the inactive GDP-bound state. This regulation influences cytoskeletal dynamics, cell migration, and signaling pathways critical for immune responses, neuronal development, and cancer progression. ARHGAP15 is highly expressed in hematopoietic cells, including neutrophils and macrophages, where it modulates immune cell functions such as phagocytosis and chemotaxis. Dysregulation of ARHGAP15 has been implicated in inflammatory diseases, neurodegenerative disorders, and tumor metastasis.

The antibody enables researchers to investigate ARHGAP15's expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity and validation in experimental models (e.g., human, mouse) make it valuable for elucidating ARHGAP15's roles in physiological and pathological contexts. Recent studies highlight its potential as a biomarker or therapeutic target, particularly in cancers where Rho GTPase signaling is aberrant. However, functional diversity across tissues and species necessitates careful experimental design when using this reagent. Continued research with ARHGAP15 antibodies may uncover novel mechanisms underlying cell motility, immune regulation, and disease pathways.