ANGPTL7抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00921(ANGPTL7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00921(ANGPTL7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The angiopoietin-like protein 7 (ANGPTL7) is a secreted glycoprotein belonging to the angiopoietin-like family, known for its roles in lipid metabolism, angiogenesis, and extracellular matrix remodeling. Primarily expressed in ocular tissues, including the cornea and trabecular meshwork, ANGPTL7 is implicated in regulating intraocular pressure and maintaining aqueous humor outflow homeostasis. Dysregulation of ANGPTL7 has been linked to glaucoma, a leading cause of irreversible blindness, due to its potential involvement in trabecular meshwork fibrosis and elevated intraocular pressure.

ANGPTL7 antibodies are tools developed to study the protein's function or inhibit its activity for therapeutic purposes. These antibodies enable detection of ANGPTL7 in tissues or biofluids, aiding in biomarker research for ocular diseases. In preclinical studies, neutralizing antibodies targeting ANGPTL7 have shown promise in reducing fibrosis and improving aqueous humor drainage, suggesting therapeutic potential for glaucoma. Additionally, ANGPTL7 antibodies contribute to elucidating its interactions with extracellular matrix components and signaling pathways, such as TGF-β.

Despite progress, the precise mechanisms of ANGPTL7 in disease and its broader physiological roles remain under investigation. Current research focuses on optimizing antibody specificity and exploring clinical applications, balancing efficacy with off-target risks in complex biological systems.