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TRPC7抗体

Rabbit Polyclonal TRPC7 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
TRPC7抗体
英文名称：
Rabbit Polyclonal TRPC7 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1772 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
TRPC7

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesTRP7
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TRPC7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P00767(TRPC7 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00767(TRPC7 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于TRPC7抗体的3篇文献示例(文献信息为模拟，实际引用需核实)：

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1. **文献名称**: *TRPC7 channels mediate myocardial hypertrophy through calcineurin-NFAT signaling*

**作者**: Hofmann T, et al.

**摘要**: 该研究利用特异性TRPC7抗体，通过Western blot和免疫组化技术验证了TRPC7蛋白在心脏组织中的表达。研究发现，TRPC7通过调控钙离子内流激活钙调磷酸酶(calcineurin)-NFAT通路，促进病理性心脏肥大。抗体在实验中用于阻断TRPC7功能，证实其参与心肌细胞肥大的分子机制。

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2. **文献名称**: *Neuronal TRPC7 channels regulate excitatory synapse formation*

**作者**: Xu H, et al.

**摘要**: 本研究采用TRPC7特异性抗体进行免疫荧光染色，发现TRPC7在海马神经元突触前膜富集。实验表明，TRPC7通过介导钙信号调节突触形成和神经递质释放。抗体阻断实验进一步证明TRPC7缺失导致突触可塑性受损，提示其在神经系统中的关键作用。

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3. **文献名称**: *TRPC7 as a regulator of insulin secretion in pancreatic β-cells*

**作者**: Riccio A, et al.

**摘要**: 作者通过TRPC7抗体检测其在胰岛β细胞中的表达，并利用siRNA和抗体中和实验证明TRPC7调控葡萄糖依赖性钙振荡，进而影响胰岛素分泌。研究揭示了TRPC7作为代谢疾病潜在治疗靶点的可能性。

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**注意事项**：

- 以上文献为示例，实际引用需通过PubMed、Web of Science等数据库检索真实论文。

- TRPC7抗体相关研究相对较少，建议扩展关键词(如“TRPC7 function”或“TRPC channels”)并结合具体研究领域筛选文献。

- 部分公司(如Alomone Labs、Abcam)可能提供TRPC7抗体的技术文档，但需区分研究论文与产品说明书。

       

背景信息

The TRPC7 antibody is a crucial tool for studying the Transient Receptor Potential Canonical 7 (TRPC7) protein, a member of the TRPC ion channel family. TRPC channels are non-selective cation channels permeable to Ca²⁺ and Na⁺, playing pivotal roles in cellular processes like calcium signaling, cell proliferation, and sensory transduction. TRPC7. encoded by the TRPC7 gene, forms homomeric or heteromultimeric complexes with other TRPC subunits, contributing to receptor-operated or store-operated calcium entry pathways. Its expression is documented in various tissues, including the brain, heart, and kidneys, implicating it in neurological, cardiovascular, and renal functions.

TRPC7 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TRPC7 expression, localization, and post-translational modifications. These antibodies aid in exploring TRPC7's physiological roles, such as modulating synaptic plasticity, cardiac hypertrophy, or hormone secretion, as well as its pathological involvement in diseases like neurodegeneration, hypertension, or cancer. Due to high sequence homology among TRPC family members (TRPC1–7), antibody specificity is a critical challenge. High-quality TRPC7 antibodies are typically validated using knockout cell lines or tissues to minimize cross-reactivity.

Research utilizing TRPC7 antibodies continues to uncover its regulatory mechanisms, including interactions with signaling proteins or lipids. These studies highlight TRPC7's potential as a therapeutic target, driving the development of selective modulators. However, functional redundancy within the TRPC family and limited isoform-specific pharmacological tools underscore the importance of reliable TRPC7 antibodies in advancing mechanistic insights. Commercial TRPC7 antibodies are available as monoclonal or polyclonal variants, often accompanied by validation data to ensure reproducibility in diverse experimental models.

       
TRPC7抗体;TRPC7;TRPC7 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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