TRAF3IP3抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231 and Hela cell, Rat liver tissue lysates, Primary antibody: P00755(TRAF3IP3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P00755(TRAF3IP3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00755(TRAF3IP3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The TRAF3IP3 (TRAF3-interacting protein 3) antibody targets a protein encoded by the TRAF3IP3 gene, also known as CKIP-3 or CKIP3. This gene encodes an adaptor protein involved in regulating immune signaling pathways, particularly those linked to NF-κB and MAPK cascades. TRAF3IP3 interacts with TRAF3 (TNF receptor-associated factor 3), a key mediator in innate and adaptive immune responses, modulating B-cell receptor signaling and cytokine production. Structurally, TRAF3IP3 contains a TRAF-binding domain and a coiled-coil region, facilitating protein-protein interactions.

Research highlights its role in immune homeostasis, inflammation, and oncogenesis. Dysregulation of TRAF3IP3 has been implicated in B-cell malignancies, autoimmune disorders (e.g., rheumatoid arthritis), and neurodegenerative diseases. Its involvement in NF-κB activation links it to pathways driving cell survival, proliferation, and inflammation.

TRAF3IP3 antibodies are widely used in immunoblotting (Western blot), immunofluorescence, and co-immunoprecipitation to study protein expression, localization, and molecular interactions. Commercial antibodies are available from suppliers like Abcam and Cell Signaling Technology. These tools help elucidate TRAF3IP3’s regulatory mechanisms in disease models, aiding therapeutic target discovery. Ongoing studies focus on its dual roles as a tumor suppressor or promoter, depending on cellular context and signaling milieu.