TPH1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: P04464(PLAT Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04464(PLAT Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04464(PLAT Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

TPH1 (tryptophan hydroxylase isoform 1) is a rate-limiting enzyme responsible for serotonin synthesis in peripheral tissues, converting tryptophan to 5-hydroxytryptophan (5-HTP), which is later decarboxylated to serotonin (5-HT). Unlike TPH2. which is primarily expressed in the central nervous system, TPH1 is predominantly found in the gut, pineal gland, and other non-neuronal tissues. TPH1 plays a critical role in regulating gastrointestinal function, vascular tone, and platelet aggregation.

Antibodies targeting TPH1 are essential tools for studying serotonin-related pathways in physiological and pathological contexts. They are widely used in immunohistochemistry, Western blotting, and ELISA to localize TPH1 expression, quantify protein levels, or investigate its involvement in diseases such as irritable bowel syndrome, carcinoid tumors, and mood disorders. TPH1 overexpression has been linked to neuroendocrine tumors, making its antibodies valuable in cancer research. Additionally, studies using TPH1 antibodies have helped elucidate the gut-brain axis by exploring serotonin's peripheral vs. central roles.

These antibodies are often validated for species specificity (e.g., human, mouse, rat) to ensure experimental accuracy. As serotonin dysregulation is implicated in numerous conditions, TPH1 antibodies remain crucial for advancing research in pharmacology, neurobiology, and metabolic disorders.