基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 TNFAIP1抗体 TNFAIP1抗体
  • TNFAIP1抗体
  • TNFAIP1抗体
  • TNFAIP1抗体

1/3

TNFAIP1抗体

Rabbit Polyclonal TNFAIP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
TNFAIP1抗体
英文名称：
Rabbit Polyclonal TNFAIP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1767 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
TNFAIP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesB12; B61; EDP1; BTBD34; hBACURD2
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human TNFAIP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lo2 and huvec cell, Primary antibody: P00748(TNFAIP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P00748(TNFAIP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00748(TNFAIP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于TNFAIP1抗体的模拟参考文献示例(文献为虚构，仅供格式参考)：

---

1. **文献名称**: *TNFAIP1 Antibody Characterization and Its Role in Inflammation*

**作者**: Lee, S., et al.

**摘要**: 该研究开发了一种特异性识别TNFAIP1蛋白的单克隆抗体，并通过Western blot和免疫荧光验证其在细胞系中的表达。实验表明TNFAIP1在炎症反应中通过与NF-κB通路相互作用调控细胞因子释放。

2. **文献名称**: *TNFAIP1 Expression in Colorectal Cancer: Diagnostic Implications*

**作者**: Zhang, Y., et al.

**摘要**: 利用TNFAIP1抗体对结直肠癌组织进行免疫组化分析，发现TNFAIP1在肿瘤组织中显著高表达，且与患者预后不良相关，提示其可能作为潜在的生物标志物。

3. **文献名称**: *TNFAIP1 Knockdown via Antibody-Mediated Targeting Suppresses Tumor Growth*

**作者**: Patel, R., & Kumar, V.

**摘要**: 研究基于TNFAIP1抗体设计抗体-药物偶联物(ADC)，在体内外实验中证明其可通过靶向TNFAIP1抑制肿瘤细胞增殖并诱导凋亡，为癌症治疗提供新策略。

4. **文献名称**: *Interactome Analysis of TNFAIP1 Using Co-Immunoprecipitation*

**作者**: Gomez, M., et al.

**摘要**: 通过TNFAIP1抗体进行免疫共沉淀实验，鉴定了TNFAIP1与多个DNA损伤修复蛋白的相互作用，揭示了其在基因组稳定性维持中的潜在功能。

---

注：以上文献为模拟内容，实际研究中建议通过PubMed或Web of Science等数据库检索真实文献。

       

背景信息

TNFAIP1 (Tumor Necrosis Factor Alpha-Induced Protein 1), also known as B12 or EDP1. is a ubiquitously expressed protein initially identified as a gene upregulated by TNF-α signaling. It plays roles in diverse cellular processes, including apoptosis, cell proliferation, and inflammatory responses. Structurally, TNFAIP1 contains a BTB/POZ domain, which mediates protein-protein interactions, and a BACK domain, suggesting involvement in ubiquitination or transcriptional regulation. It interacts with proteins like TRAF2 and IκBα, influencing NF-κB signaling, and modulates Wnt/β-catenin pathways, linking it to cancer progression and neurodegenerative diseases.

Antibodies targeting TNFAIP1 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to explore TNFAIP1's role in pathological contexts. For example, studies using TNFAIP1 antibodies have revealed its upregulation in certain cancers (e.g., gliomas, hepatocellular carcinoma) and its association with poor prognosis. In neurological disorders, altered TNFAIP1 levels correlate with neuronal apoptosis and oxidative stress.

Commercially available TNFAIP1 antibodies are typically validated for specificity across human, mouse, and rat samples. Researchers must optimize experimental conditions (e.g., antigen retrieval for IHC) due to variability in tissue fixation or protein modifications. Overall, TNFAIP1 antibodies continue to advance mechanistic insights into its dual roles as a tumor suppressor or promoter, depending on cellular context, and its potential as a therapeutic target.

       
TNFAIP1抗体;TNFAIP1;TNFAIP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

TNFAIP1抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价