TEKT1抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, Lncap cells, Primary antibody: P00745(TEKT1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lymphoma tissue using P00745(TEKT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00745(TEKT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

TEKT1 (tektin-1) is a member of the tektin family of filamentous proteins, which are integral components of microtubule-based structures such as cilia, flagella, and centrioles. Predominantly expressed in the testis, TEKT1 is localized to the outer dense fibers of sperm flagella, playing a critical role in maintaining structural integrity and facilitating sperm motility. Its function is closely linked to male fertility, as mutations or dysregulation of TEKT1 have been associated with asthenozoospermia (reduced sperm motility) and infertility.

TEKT1 antibodies are valuable tools for studying sperm development, ciliary biology, and reproductive disorders. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TEKT1 expression, localization, and potential abnormalities in clinical or research samples. Beyond reproductive health, emerging studies suggest TEKT1 may have roles in certain cancers (e.g., gliomas) where ciliary dysfunction is implicated. These antibodies also aid in exploring TEKT1's interactions with other cytoskeletal proteins, providing insights into microtubule dynamics and cellular mechanobiology. Commercial TEKT1 antibodies are typically raised in rabbits or mice, with validation in human and model organisms, supporting both diagnostic and basic research applications.