F9抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P00736(F9 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00736(F9 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The F9 antibody is associated with coagulation Factor IX (FIX), a vitamin K-dependent serine protease critical for blood clotting. FIX is synthesized in the liver and plays a pivotal role in the intrinsic coagulation pathway, where it is activated to FIXa, forming a complex with Factor VIIIa to activate Factor X. Deficiencies or dysfunction of FIX cause Hemophilia B, an X-linked recessive bleeding disorder.

Antibodies targeting FIX (commonly referred to as "inhibitors") are rare but significant complications in Hemophilia B treatment. These neutralizing antibodies arise in approximately 1-3% of patients receiving recombinant or plasma-derived FIX replacement therapy, leading to reduced therapeutic efficacy and increased bleeding risk. Their development is linked to genetic mutations causing severe FIX deficiency (<1% activity) or large gene deletions.

Research on F9 antibodies also explores therapeutic applications. Bispecific antibodies mimicking FIXa-FVIIIa function (e.g., emicizumab) have been developed to bypass FIX inhibitors in Hemophilia A, indirectly highlighting FIX's role. Additionally, monoclonal antibodies targeting FIX/FIXa are investigated as anticoagulants or for modulating thrombosis. Recent advances include engineered FIX variants with reduced immunogenicity and gene therapies (e.g., adeno-associated virus vectors) to induce endogenous FIX expression, potentially minimizing antibody risks.

Understanding F9 antibodies remains vital for improving Hemophilia B management and developing safer hemostatic therapies.