SPATA13抗体

The SPATA13 antibody targets the protein encoded by the SPATA13 gene (Spermatogenesis-Associated Protein 13), which is implicated in cellular processes such as cell migration, adhesion, and signaling. SPATA13. also known as ASEF2 (APC-Stimulated guanine nucleotide Exchange Factor 2), functions as a guanine nucleotide exchange factor (GEF) for Rac1 and Cdc42 GTPases, regulating cytoskeletal dynamics and cell polarity. It plays dual roles in cancer biology, acting as a metastasis promoter in certain cancers (e.g., colorectal) while showing tumor-suppressive activity in others. In reproductive biology, SPATA13 is linked to spermatogenesis, though its exact role remains under investigation. Antibodies against SPATA13 are utilized to study its expression, localization, and function in diverse contexts, including cancer progression, neuronal development, and male infertility. Commercial SPATA13 antibodies are typically validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies explore its interaction with pathways like Wnt/β-catenin and its potential as a therapeutic target. Research using SPATA13 antibodies contributes to understanding its context-dependent roles in disease mechanisms and normal physiological processes.