SYT7抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lncap cells, SKOV3 cells, Primary antibody: P00715(SYT7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00715(SYT7 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P00715(SYT7 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

The SYT7 antibody is a crucial tool for studying Synaptotagmin-7 (SYT7), a calcium-sensing protein belonging to the synaptotagmin family. SYT7 is widely expressed in tissues, particularly in the brain, endocrine cells, and immune cells, where it regulates membrane trafficking, vesicle fusion, and calcium-dependent exocytosis. It plays roles in diverse physiological processes, including synaptic transmission, lysosomal exocytosis, and plasma membrane repair. The SYT7 antibody specifically detects SYT7 protein isoforms, enabling researchers to investigate its expression, localization, and function in cellular and animal models.

This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes knockout controls to confirm specificity. Research applications span neuroscience (studying synaptic plasticity or neurodegenerative diseases), endocrinology (hormone secretion mechanisms), and immunology (immune cell secretion pathways). SYT7 dysregulation has been linked to conditions such as diabetes, cancer metastasis, and neuronal disorders, making the antibody valuable for exploring disease mechanisms.

Developed in various host species (e.g., rabbit, mouse), SYT7 antibodies are available as monoclonal or polyclonal forms, with selection depending on experimental needs. Proper validation ensures minimal cross-reactivity with other synaptotagmin family members (e.g., SYT1. SYT4), which share structural homology but distinct functions. Overall, SYT7 antibodies are indispensable for deciphering SYT7’s role in cellular communication and pathology.