SEMA3C抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P00677(SEMA3C Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P00677(SEMA3C Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

**Background of SEMA3C Antibody**

SEMA3C (Semaphorin-3C) is a secreted glycoprotein belonging to the semaphorin family, known for its role in axon guidance during neural development. Beyond the nervous system, SEMA3C regulates diverse biological processes, including cell migration, angiogenesis, immune response, and cancer progression. Structurally, it contains a conserved Sema domain, a PSI (plexin-semaphorin-integrin) domain, and an immunoglobulin-like domain, enabling interactions with receptors such as plexins and neuropilins. These interactions activate downstream signaling pathways (e.g., Rho GTPases, MAPK) to modulate cytoskeletal dynamics and gene expression.

In cancer, SEMA3C is often overexpressed in tumors (e.g., prostate, breast, pancreatic) and linked to tumor growth, metastasis, and therapy resistance by promoting angiogenesis, epithelial-mesenchymal transition (EMT), and survival signaling. SEMA3C-targeting antibodies are critical tools for studying its expression, localization, and functional roles. They enable applications like Western blotting, immunohistochemistry, and flow cytometry to assess protein levels in tissues or cell lines. Function-blocking SEMA3C antibodies are also explored for therapeutic potential, as they may inhibit tumor-promoting signaling by neutralizing SEMA3C or disrupting receptor binding.

Research on SEMA3C antibodies continues to advance their diagnostic and therapeutic utility, though challenges remain in optimizing specificity and efficacy for clinical translation.