SERP1抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P00639(SERP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P00639(SERP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

SERP1 (Stress-associated Endoplasmic Reticulum Protein 1), also known as RAMP4 or CRELD2. is a chaperone protein localized in the endoplasmic reticulum (ER). It plays a role in modulating ER stress responses by assisting in the folding and quality control of newly synthesized glycoproteins, particularly under stress conditions. SERP1 interacts with the ER-associated degradation (ERAD) machinery and components of the unfolded protein response (UPR), contributing to cellular adaptation during protein misfolding or metabolic disturbances.

SERP1 antibodies are immunological tools used to detect and study the expression, localization, and function of SERP1 in various biological contexts. These antibodies have been instrumental in research linking SERP1 to diseases such as neurodegenerative disorders (e.g., Alzheimer’s disease), cancer, and cardiovascular conditions, where ER stress dysregulation is implicated. Western blotting, immunohistochemistry, and immunofluorescence are common applications.

Structurally, SERP1 contains conserved thioredoxin-like domains and glycosylation sites, which antibodies often target for specificity. Studies using SERP1 antibodies have revealed its upregulated expression during hypoxia, oxidative stress, and inflammation, suggesting its role as a potential biomarker or therapeutic target. Validation of these antibodies emphasizes their importance in elucidating ER stress pathways and disease mechanisms.