MSH3抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P00543(MSH3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P00543(MSH3 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P00543(MSH3 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

MSH3 antibody targets the MutS homolog 3 (MSH3) protein, a key component of the DNA mismatch repair (MMR) system. MSH3 belongs to the MutS family of proteins, which play a critical role in maintaining genomic stability by recognizing and correcting base-pair mismatches and insertion-deletion loops (IDLs) during DNA replication. It primarily functions as part of the MutSβ heterodimer, formed by pairing with MSH2. to repair larger mismatches (up to 16 nucleotides) that escape detection by MutSα (MSH2-MSH6).

Alterations in MSH3 expression or function are linked to microsatellite instability (MSI) and have been implicated in hereditary and sporadic cancers, including colorectal, endometrial, and gastric cancers. MSH3 antibodies are widely used in research and diagnostics to assess protein expression levels via immunohistochemistry (IHC) or immunoblotting, aiding in the identification of MMR-deficient tumors. Such deficiencies may indicate susceptibility to immunotherapy or inform genetic counseling for hereditary cancer syndromes.

Additionally, MSH3 antibodies contribute to studies exploring the molecular mechanisms of DNA repair, cancer progression, and therapy resistance. Recent interest has focused on MSH3's potential role in trinucleotide repeat disorders and its interaction with PARP inhibitors in synthetic lethal approaches for cancer treatment. Despite its significance, MSH3 mutations are less commonly associated with Lynch syndrome compared to other MMR genes like MLH1 or MSH2.