MMP15抗体

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     Western blot analysis of lysate from mouse testis tissue lysate, using Mouse Mos Antibody (C-term)(Cat. #P31514). P31514 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.    

  
  

**Background of MMP15 Antibody**

Matrix Metalloproteinase 15 (MMP15), also known as membrane-type MMP-2 (MT2-MMP), is a member of the MMP family, which plays critical roles in extracellular matrix (ECM) remodeling, cell migration, and tissue repair. As a membrane-anchored protease, MMP15 contains a catalytic domain, a transmembrane region, and a cytoplasmic tail, enabling localized proteolytic activity at the cell surface. It activates pro-MMP2. facilitating ECM degradation, and processes substrates like collagen, laminin, and adhesion molecules, influencing cellular signaling and microenvironment interactions.

MMP15 is implicated in physiological processes such as embryogenesis, angiogenesis, and wound healing, but its dysregulation is linked to pathological conditions, including cancer progression, metastasis, and inflammatory diseases. Overexpression of MMP15 in tumors correlates with enhanced invasion, angiogenesis, and poor prognosis, making it a potential therapeutic target.

MMP15 antibodies are essential tools for detecting and quantifying MMP15 expression in research. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its localization, regulation, and function in disease models. These antibodies aid in exploring MMP15's mechanistic roles and evaluating its diagnostic or prognostic value in cancer and other disorders. Developing specific and sensitive MMP15 antibodies remains crucial for advancing research into targeted therapies and understanding MMP-related pathologies.