MFN1抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P00527(MFN1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of MFN1 Antibody**

Mitofusin-1 (MFN1) is a mitochondrial outer membrane GTPase critical for regulating mitochondrial fusion, a dynamic process essential for maintaining mitochondrial morphology, function, and quality control. It works in concert with MFN2 to mediate tethering of adjacent mitochondria, enabling the merging of membranes and content exchange. MFN1 is particularly important in energy-demanding tissues like skeletal muscle, heart, and brain, where mitochondrial dynamics are tightly linked to cellular health.

MFN1 antibodies are immunological tools designed to detect and quantify MFN1 protein expression in research applications. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study mitochondrial dynamics in physiological and pathological contexts. Dysregulation of MFN1 has been implicated in neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), cardiovascular diseases, and metabolic syndromes, making its detection vital for understanding disease mechanisms.

Additionally, MFN1 antibodies aid in exploring crosstalk between mitochondrial fusion-fission balance and processes like apoptosis, mitophagy, and oxidative stress. Commercial MFN1 antibodies are often validated for specificity using knockout cell lines or tissues to ensure accurate targeting. As mitochondrial dysfunction gains attention in aging and therapy development, MFN1 antibodies remain pivotal in advancing research on cellular bioenergetics and organelle homeostasis.