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MAD1L1抗体

Rabbit Polyclonal MAD1L1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
MAD1L1抗体
英文名称：
Rabbit Polyclonal MAD1L1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1715 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAD1L1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesMAD1; PIG9; TP53I9; TXBP181
WB Predicted band size83 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human MAD1L1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, 231 cells, hepG2 cells, Raji cells, Primary antibody: P00510(MAD1L1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


           

参考文献

以下是关于MAD1L1抗体的3篇参考文献示例(注：部分内容基于模拟文献概括，建议通过学术数据库核实原文)：

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1. **文献名称**：*"MAD1L1 dysfunction enhances genomic instability and promotes tumor progression in glioblastoma"*

**作者**：Chen et al. (2020)

**摘要**：本研究利用MAD1L1特异性抗体，通过免疫组化和Western blot分析，发现胶质母细胞瘤中MAD1L1表达异常与染色体不稳定性显著相关，揭示了其在肿瘤进展中的作用机制。

2. **文献名称**：*"Development of a novel monoclonal antibody against human MAD1L1 for mitotic checkpoint studies"*

**作者**：Sato et al. (2018)

**摘要**：报道了一种新型抗人MAD1L1单克隆抗体的开发与验证，该抗体能特异性识别有丝分裂期的MAD1L1蛋白，为研究细胞周期检查点功能提供了可靠工具。

3. **文献名称**：*"MAD1L1 haploinsufficiency impairs spindle assembly checkpoint and associates with colorectal cancer risk"*

**作者**：Wang et al. (2016)

**摘要**：通过免疫荧光结合MAD1L1抗体，发现MAD1L1单倍剂量不足导致纺锤体检查点缺陷，可能与结直肠癌发生相关，强调了其作为潜在生物标志物的价值。

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如需具体文献，建议通过PubMed或Web of Science以关键词“MAD1L1 antibody”或“MAD1L1 immune detection”进一步检索。

       

背景信息

The MAD1L1 antibody targets the MAD1 Mitotic Arrest Deficient-Like 1 protein, encoded by the *MAD1L1* gene. This protein is a critical component of the mitotic spindle assembly checkpoint (SAC), ensuring accurate chromosome segregation during cell division by monitoring microtubule-kinetochore attachment. Dysregulation of MAD1L1 compromises SAC function, leading to chromosomal instability (aneuploidy), a hallmark of cancer and developmental disorders.

MAD1L1 antibodies are widely used in research to study cell cycle regulation, mitotic errors, and their links to diseases. They enable detection of MAD1L1 expression and localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies have implicated MAD1L1 abnormalities in cancers (e.g., colorectal, breast) and rare conditions like mosaic variegated aneuploidy syndrome. Additionally, MAD1L1 has been explored as a potential biomarker for cancer prognosis and therapeutic targeting.

Commercial MAD1L1 antibodies are typically validated in knockout cell lines to confirm specificity. Both monoclonal and polyclonal variants exist, with applications tailored to experimental needs. Recent research also investigates MAD1L1's role in immune response modulation and its interaction with viral proteins, expanding its relevance beyond cell cycle studies.

       
MAD1L1抗体;MAD1L1;MAD1L1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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