KLF15抗体

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     Western blot analysis of Factor XIIIa in Jurkat lysates using Factor XIIIa antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human colon cancer using Factor XIIIa antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

The Krüppel-like factor 15 (KLF15) antibody is a tool used to detect and study KLF15. a transcription factor belonging to the Krüppel-like family, characterized by its zinc finger DNA-binding domain. KLF15 plays critical roles in regulating metabolism, tissue remodeling, and circadian rhythms. It is expressed in metabolic tissues, including liver, adipose, skeletal muscle, and heart, where it modulates glucose, lipid, and amino acid metabolism by targeting genes like *PGC-1α*, *GLUT4*, and *BCAT2*. KLF15 also influences cardiovascular function, fibrosis, and cellular differentiation.

KLF15 antibodies are essential for investigating its expression patterns, interactions, and regulatory mechanisms in diseases such as diabetes, heart failure, and metabolic syndrome. Studies highlight KLF15's dual role in pathophysiological contexts—promoting insulin sensitivity while potentially exacerbating fibrosis under stress. Antibodies enable techniques like Western blot, immunofluorescence, and chromatin immunoprecipitation (ChIP), aiding in understanding KLF15's tissue-specific effects and crosstalk with pathways like PPARs and mTOR.

Commercial KLF15 antibodies are typically monoclonal or polyclonal, validated for specificity across species (human, mouse, rat). Research using these antibodies has unveiled KLF15's therapeutic potential, including its role in circadian metabolic disorders and as a biomarker for cardiac hypertrophy. However, challenges remain in standardizing antibody performance across experimental conditions, necessitating careful validation. Overall, KLF15 antibodies are vital for dissecting its contributions to metabolic homeostasis and disease.