HCK抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P00416(HCK Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00416(HCK Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00416(HCK Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

HCK (Hematopoietic Cell Kinase) is a member of the Src family of tyrosine kinases, primarily expressed in hematopoietic cells, including myeloid cells, B lymphocytes, and natural killer cells. It plays a critical role in immune cell signaling, regulating processes like phagocytosis, cytokine production, and cell differentiation. HCK is activated by interactions with cell surface receptors (e.g., integrins, Fc receptors) and downstream signaling molecules, influencing pathways such as PI3K/AKT and MAPK. Dysregulation of HCK has been linked to hematological malignancies, chronic inflammation, and autoimmune disorders.

HCK antibodies are essential tools for studying its expression, activation, and functional roles. They enable detection of HCK in immunoblotting, immunohistochemistry, and flow cytometry, aiding research into its involvement in diseases like leukemia and rheumatoid arthritis. Therapeutic strategies targeting HCK, including inhibitory antibodies or small-molecule inhibitors, are under exploration to modulate aberrant immune responses or oncogenic signaling. Recent studies also highlight HCK's dual role in tumor microenvironments, acting as both a promoter of cancer progression and a mediator of anti-tumor immunity, making it a nuanced target for precision therapies.