UGCG抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, MCF7, A375 cell lysates, Primary antibody: P00397(UGCG Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00397(UGCG Antibody) at dilution 1/95. (Original magnification: ×200)    

  
  

The UDP-glucose ceramide glucosyltransferase (UGCG) antibody is a crucial tool for studying the enzyme UGCG, a key regulator in glycosphingolipid (GSL) biosynthesis. UGCG catalyzes the transfer of glucose to ceramide, forming glucosylceramide (GlcCer), the foundational step in GSL synthesis. These lipids are essential components of cell membranes, influencing signal transduction, cell adhesion, and membrane trafficking. Dysregulation of UGCG activity is linked to pathological conditions, including cancer, neurodegenerative diseases, and lysosomal storage disorders like Gaucher’s disease.

In cancer research, UGCG overexpression is associated with multidrug resistance and tumor progression, as GSLs modulate survival pathways and drug efflux mechanisms. UGCG antibodies enable detection of enzyme expression levels in tissues or cell lines, aiding mechanistic studies. In neuroscience, altered GSL metabolism due to UGCG dysfunction is implicated in Parkinson’s and Alzheimer’s diseases. Additionally, UGCG inhibitors are explored as therapeutic agents, necessitating precise antibody-based quantification in preclinical models.

UGCG antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Their specificity is validated via knockout controls or enzymatic assays. Research also focuses on UGCG’s role in viral entry mechanisms, as certain viruses exploit GSL-rich membrane domains for infection. Understanding UGCG’s biological and pathological roles underscores the antibody’s importance in both basic science and translational applications.