GAS7抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: P00394(GAS7 Antibody) at dilution 1/625, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00394(GAS7 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P00394(GAS7 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The Growth Arrest-Specific 7 (GAS7) protein, encoded by the GAS7 gene, belongs to the GAS family involved in cell growth regulation. It is predominantly expressed in the brain, particularly in neurons, and plays critical roles in cell differentiation, neurite outgrowth, and cell cycle arrest. Structurally, GAS7 contains an N-terminal FCH domain that facilitates membrane deformation and a C-terminal SH3-binding domain enabling interactions with cytoskeletal proteins like WASL (WASP-like protein). Alternative splicing generates multiple GAS7 isoforms with distinct tissue distributions and functional properties.

GAS7 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate GAS7's role in neural development, tumor suppression, and diseases like neuroblastoma, glioblastoma, and muscular dystrophy. Dysregulation of GAS7 has been linked to cancer progression, as it modulates cytoskeletal dynamics and influences cell migration or invasion. Additionally, GAS7 interacts with pathways involving p53 and Wnt/β-catenin, highlighting its regulatory complexity.

Research utilizing GAS7 antibodies has expanded insights into its dual roles in neuroprotection and oncogenesis, making it a potential biomarker or therapeutic target. However, isoform-specific antibody validation remains crucial due to structural variations among splice variants.