GADD45G抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P00388(GADD45G Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The GADD45G (Growth Arrest and DNA Damage-Inducible 45 Gamma) antibody is a key tool for studying the GADD45G protein, a member of the evolutionarily conserved GADD45 family involved in cellular stress responses. GADD45G is induced by various stressors, including DNA damage, oxidative stress, and cytokine signaling. It regulates critical processes such as cell cycle arrest (primarily at G1/S and G2/M checkpoints), DNA repair, apoptosis, and cellular differentiation by interacting with cell cycle proteins (e.g., CDKs, PCNA) and signaling pathways (e.g., p38 MAPK, JNK). Its role in tumor suppression, particularly in silencing certain cancers through promoter hypermethylation, has drawn significant research interest.

The GADD45G antibody enables detection and quantification of endogenous GADD45G protein levels in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore GADD45G's expression patterns under stress conditions, its interplay with p53-dependent/independent pathways, and its involvement in diseases like cancer, neurodegenerative disorders, and immune dysregulation. Validated antibodies with high specificity are crucial, as GADD45 family members (GADD45A, GADD45B, GADD45G) share structural homology. Recent studies also investigate its potential as a biomarker or therapeutic target, emphasizing the antibody's utility in both basic research and translational applications.