FOXR2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell, Primary antibody: P00376(FOXR2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P00376(FOXR2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00376(FOXR2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The FOXR2 antibody is a research tool designed to target the FOXR2 protein, a member of the Forkhead box (FOX) family of transcription factors. FOX proteins play critical roles in regulating gene expression during development, differentiation, and disease. FOXR2. specifically, is a relatively understudied member of this family. It shares a conserved Forkhead DNA-binding domain but exhibits distinct expression patterns and functions compared to other FOX proteins. Emerging studies suggest FOXR2 may be involved in oncogenesis, with elevated expression observed in certain cancers, including neuroblastoma and glioblastoma. Its exact mechanisms, however, remain unclear, though it is hypothesized to influence cell proliferation, survival, or metabolic reprogramming.

FOXR2 antibodies are primarily used in biomedical research to detect and quantify FOXR2 protein levels in tissues or cell lines, aiding in studies of its biological roles and pathological relevance. These antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available FOXR2 antibodies are typically monoclonal or polyclonal, with specificity confirmed via knockout controls.

Interest in FOXR2 has grown due to its potential as a diagnostic marker or therapeutic target, particularly in cancers with limited treatment options. However, further research is needed to elucidate its signaling pathways and interactions. Current challenges include optimizing antibody specificity and understanding FOXR2's context-dependent roles in different tissues or malignancies.