FOSL2抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P03029(DHFR Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03029(DHFR Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The FOSL2 antibody is a tool used to detect FOS-like antigen 2 (FOSL2), a member of the FOS family of transcription factors. FOSL2. also known as Fra-2. forms part of the AP-1 (Activator Protein 1) complex by dimerizing with JUN proteins, regulating gene expression in response to stress, cytokines, and growth signals. It plays roles in cell proliferation, differentiation, and apoptosis, and is implicated in cancer, immune responses, and tissue remodeling.

FOSL2 antibodies are typically generated in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. These antibodies enable the study of FOSL2 expression, localization, and function through techniques like Western blotting (detecting ~40 kDa protein), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is validated via knockout controls or siRNA knockdown.

Research using FOSL2 antibodies highlights its dual roles: it promotes tumor progression in certain cancers (e.g., breast, lung) but acts as a tumor suppressor in others. Dysregulation of FOSL2 is linked to fibrosis, autoimmune diseases, and metabolic disorders. The antibody is crucial for exploring FOSL2's regulatory mechanisms, including post-translational modifications (e.g., phosphorylation) and interactions with signaling pathways like MAPK. Its versatility makes it essential for both basic research and clinical biomarker studies.