DUSP10抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P00362(DUSP10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P00362(DUSP10 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00362(DUSP10 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DUSP10 antibody is a crucial tool in studying the dual-specificity phosphatase 10 (DUSP10), also known as MAP kinase phosphatase 5 (MKP5). DUSP10 belongs to the dual-specificity phosphatase family, which regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and threonine residues. Specifically, DUSP10 inactivates stress-activated MAPKs, such as p38 and JNK, playing a pivotal role in modulating cellular responses to stress, inflammation, and apoptosis. It is highly expressed in immune tissues, heart, and skeletal muscle, and its activity is implicated in immune regulation, metabolic disorders, and cancer progression.

Researchers utilize DUSP10 antibodies to detect and quantify endogenous DUSP10 protein levels in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate DUSP10's spatial-temporal expression patterns, post-translational modifications, and interactions with signaling partners. Studies have linked DUSP10 dysregulation to pathologies such as obesity, cardiac hypertrophy, and neurodegenerative diseases, highlighting its potential as a therapeutic target. For instance, DUSP10 knockout models demonstrate exacerbated inflammation and insulin resistance, underscoring its protective role in metabolic stress. The antibody's specificity and validation (e.g., via knockout validation or peptide blocking) are critical for ensuring reliable data in both basic and translational research contexts.